The Sweetwater Bikeway runs along the Sweetwater River from a parklike setting opposite the Plaza Bonita Shopping Center on the trail's east side to the yacht harbor at the mouth of the river. The trail follows the river under numerous roads to reach the bay. At its western end, it connects to the Bayshore Bikeway. Farther up the Sweetwater watershed, there are numerous hiking and equestrian trails through Sweetwater Regional Park. Restaurants are located at both ends of the trail and a food court is available in the mall.
Access to the Sweetwater Bikeway is available at 2nd Avenue, W33rd, Hoover Avenue, and Bonita Road. Parking is available at all entrances. Bathrooms and parking are also available at Pepper Park two blocks from the west end of the trail.